Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 12, Issue 10, Pages 1247-1261Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.16463
Keywords
disease; nutrient; microRNA; mTOR; skeletal myogenesis; signaling pathways
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Funding
- National Basic Research Program of China [2012CB124701]
- National Natural Science Foundation of China [31372323]
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Skeletal muscle is a remarkably complicated organ comprising many different cell types, and it plays an important role in lifelong metabolic health. Nutrients, as an external regulator, potently regulate skeletal muscle development through various internal regulatory factors, such as mammalian target of rapamycin (mTOR) and microRNAs (miRNAs). As a nutrient sensor, mTOR, integrates nutrient availability to regulate myogenesis and directly or indirectly influences microRNA expression. MiRNAs, a class of small non-coding RNAs mediating gene silencing, are implicated in myogenesis and muscle-related diseases. Meanwhile, growing evidence has emerged supporting the notion that the expression of myogenic miRNAs could be regulated by nutrients in an epigenetic mechanism. Therefore, this review presents a novel insight into the cell signaling network underlying nutrient-mTOR-miRNA pathway regulation of skeletal myogenesis and summarizes the epigenetic modifications in myogenic differentiation, which will provide valuable information for potential therapeutic intervention.
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