Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 12, Issue 7, Pages 898-910Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.14430
Keywords
Long noncoding RNA; Atherosclerosis; Gene regulation
Categories
Funding
- Shanghai Sailing Program [16YF1409500]
- Fundamental Research Funds for the Central Universities [2014KJ086]
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Long noncoding RNAs belong to a class of noncoding RNAs longer than 200 nucleotides with the epigenetic regulation potential. As a novel molecular regulator, IncRNAs are often dysregulated in various pathological conditions and display multiple functions in a wide range of biological processes. Given that recent studies have indicated that IncRNAs are involved in atherosclerosis-related smooth muscle cell, endothelial cell, macrophage and lipid metabolism regulation, it is pertinent to understand the potential function of IncRNAs in atherosclerosis development. This review will highlight the recent updates of IncRNAs in atherogenesis and also discuss their potential roles as novel therapeutic targets.
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