Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 93, Issue -, Pages 1390-1401Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2016.06.043
Keywords
Gelatin; Collagen; Biomimetic scaffolds; Bone tissue engineering; Composite scaffolds
Funding
- Department of Biotechnology, Government of India
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Bone is a natural composite material consisting of an organic phase (collagen) and a mineral phase (calcium phosphate, especially hydroxyapatite). The strength of bone is attributed to the apatite, while the collagen fibrils are responsible for the toughness and visco-elasticity. The challenge in bone tissue engineering is to develop such biomimetic composite scaffolds, having a balance between biological and biomechanical properties. This review summarizes the current state of the field by outlining composite scaffolds made of gelatin/collagen in combination with bioactive ceramics for bone tissue engineering application. (C) 2016 Elsevier B.V. All rights reserved.
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