Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 82, Issue -, Pages 1023-1027Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2015.10.027
Keywords
Sodium alginate; Tamarind seed polysaccharide; Ionotropic-gelation
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The paper describes the preparation, characterization, in vitro swelling and in vitro drug release of metformin HCl-loaded tamarind seed polysaccharide (TSP)-alginate beads were prepared by ionotropic-gelation technique and using CaCl2 as cross-linker. The prepared beads exhibited 32.73 +/- 1.41% of drug loading (%), 94.86 +/- 3.92% of drug encapsulation efficiency (%), and 1.24 +/- 0.07 mm of average bead size. The bead surface morphology was analyzed by SEM. The drug-polymer interaction in the bead matrix was analyzed by FTIR analyses. These metformin HCl-loaded ionotropically gelled TSP-alginate beads demonstrated sustained in vitro drug release profile over 10h. These in vitro drug release exhibited pH-dependent drug release behavior. The in vitro drug release from these metformin HCl-loaded beads followed controlled-release (zero-order) pattern with super case-II transport mechanism. The swelling and degradation of these metformin HCl-loaded polymeric beads were found to be influenced by the pH of test mediums. (C) 2015 Elsevier B.V. All rights reserved.
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