Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 82, Issue -, Pages 381-386Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2015.11.010
Keywords
beta-Cyclodextrin; Drug release; Hollow spheres; Inclusion complexation; Stimuli-sensitivity
Funding
- National Natural Science Foundation of China [21204035, 51403096]
- Shandong Province Higher Educational Science and Technology Program [J13LD09]
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In this paper, thermo-sensitive polymeric hollow spheres assembled from sodium alginate-graft-poly(N-isopropylacrylamide) (ALG-g-PNIPAM) and beta-cyclodextrin (beta-CD) were prepared for controlled release of 5-fluorouracil (5-FU). In aqueous solutions, beta-CD and PNIPAM formed rod-like segments through inclusion complexation interactions and sodium alginate acted as coil segments, which resulted in the formation of hollow structures. The size and wall thickness of assemblies increased with the increase of beta-CD in mixtures. The lower critical solution temperature (LCST) of hollow spheres varied in the range of 35-37 degrees C. The hollow spheres exhibited high drug loading efficiency for 5-FU due to the hydrophilic cavities. The initial composition of mixtures, temperature and pH had a significant effect on the inclusion ability and drug release. Increasing temperatures above the LCST or decreasing pH to acidic conditions, a more rapid release rate was observed. (c) 2015 Elsevier B.V. All rights reserved.
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