Journal
POLYMERS
Volume 13, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/polym13244390
Keywords
three-dimensional porous scaffolds; bone extracellular matrix; bone regeneration; tissue engineering; biomaterials
Categories
Funding
- Instituto Cientifico Pfizer [469443-3213-25-XI-16]
- Novograft Laboratories [0012/2018]
- [547082]
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The use of decellularized ECM material from bovine cancellous bone to obtain a three-dimensional porous scaffold has shown promising results for potential therapeutic strategies in bone repair. The scaffold retains osteoconductive and osteoinductive properties and exhibits osteogenic potential when seeded with human Wharton's jelly mesenchymal stromal cells (hWJ-MSCs).
The use of three-dimensional porous scaffolds derived from decellularized extracellular matrix (ECM) is increasing for functional repair and regeneration of injured bone tissue. Because these scaffolds retain their native structures and bioactive molecules, in addition to showing low immunogenicity and good biodegradability, they can promote tissue repair and regeneration. Nonetheless, imitating these features in synthetic materials represents a challenging task. Furthermore, due to the complexity of bone tissue, different processes are necessary to maintain these characteristics. We present a novel approach using decellularized ECM material derived from bovine cancellous bone by demineralization, decellularization, and hydrolysis of collagen to obtain a three-dimensional porous scaffold. This study demonstrates that the three-dimensional porous scaffold obtained from bovine bone retained its osteoconductive and osteoinductive properties and presented osteogenic potential when seeded with human Wharton's jelly mesenchymal stromal cells (hWJ-MSCs). Based on its characteristics, the scaffold described in this work potentially represents a therapeutic strategy for bone repair.
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