Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine

This work demonstrates a facile electropolymerization of a dl-methionine (dl-met) conducting polymeric film on a gold nanoparticle (AuNPs)-modified glassy carbon electrode (GCE). The resulting sensor was successfully applied for the sensitive detection of paroxetine & BULL;HCl (PRX), a selective serotonin (5-HT) reuptake inhibitor (SSRIs), in its pharmaceutical formulations. The sensor was characterized morphologically using scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM) and electrochemical techniques such as differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The proposed sensor, poly (dl-met)/AuNPs-GCE, exhibited a linear response range from 5 x 10(-11) to 5 x 10(-8) M and from 5 x 10(-8) to 1 x 10(-4) M using DPV with lowest limit of detection (LOD = 1 x 10(-11) M) based on (S/N = 3). The poly (dl-met)/AuNPs-GCE sensor was successfully applied for PRX determination in three different pharmaceutical formulations with percent recoveries between 96.29% and 103.40% & PLUSMN; SD (& PLUSMN;0.02 and & PLUSMN;0.58, respectively).

Automated summary

This study demonstrated a facile electropolymerization of dl-methionine conducting polymeric film on a gold nanoparticle-modified glassy carbon electrode for sensitive detection of paroxetine HCl. The sensor showed a wide linear response range with a low detection limit, and successfully applied for PRX determination in different formulations with high percent recoveries.