Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 89, Issue -, Pages 62-69Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2016.03.009
Keywords
Aminoethy hydroxypropyl methyl cellulose; Nisin; Antioxidant activity
Funding
- National Natural Science Foundation of China [51173143, 51273156]
- Special Funds Project of Major New Products of Hubei Province [20132h0040]
- University-industry Cooperation Projects of The Ministry of Education of Guangdong province [2012B091100437]
- Ministry of Science and Technology of Small and Medium-sized Enterprises [11C26214202642, 11C26214212743]
- Zhuhai Science and Technology Plan Projects [2011B050102003]
- Wuhan Science and Technology Development [201060623262]
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Nisin grafted aminoethyl hydroxypropyl methyl cellulose (AEHPMC) was prepared by an enzyme catalyzed reaction in the presence of microbial transglutaminase (MTGase). AEHPMC was synthesized with 2-chloroethylamine hydrochloride (CEH) which was as an intermediate reactant. The parameters, which influenced the NH2% and the degree of substitution (DS), including reaction time, reaction temperature and the mass ratio of the reactants were investigated. Antioxidant activities of AEHPMC-nisin were evaluated by the scavenging activity of hydroxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. With the DS and concentration increasing of AEHPMC-nisin, the radical scavenging activity increased. The Methylthiazol tetrazolium (MTT) assay indicated that AEHPMC-nisin had low-toxicity to L929 cells. Therefore, the derivative of HPMC may show a promising potential application in biomedical, food and pharmaceutical fields. (C) 2016 Published by Elsevier B.V.
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