Journal
POLYMERS
Volume 13, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/polym13223909
Keywords
crown ether; fibroblast; functional dendron; macromolecular machine; rotaxane dendrimer
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Funding
- Hong Kong Baptist University [RC-KRPS-20-21/02]
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Second-generation type III-B rotaxane dendrons with succinimide and acetylene functional groups were successfully synthesized and characterized. A cell viability study showed low cytotoxicity of the dendrons, indicating potential for development into bio-compatible polymeric materials.
Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 mu M. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.
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