Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 93, Issue -, Pages 757-766Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2016.09.018
Keywords
Resveratrol; Phospholipid; Nanoparticles; Antioxidant activity; Control release
Funding
- Leading Human Resource Training Program of Regional Neo Industry - Ministry of Science, ICT and Future Planning [2016H1D5A1909049]
- Basic Research Laboratory Program through the National Research Foundation (NRF) - Ministry of Education of Korea [2014R1A4A1008140]
- Basic Science Research Program through the National Research Foundation (NRF) - Ministry of Education of Korea [2016R1A6A03012069]
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Despite the therapeutic effects of resveratrol, its clinical application is restricted by its poor oral bioavailability and low water solubility. To overcome these physicochemical and pharmacokinetic limitations, encapsulation of resveratrol (RV) into nanodevices has been explored. Resveratrol cross-linked chitosan nanoparticles modified with phospholipids (RVC-lipid) were synthesized using a double emulsion technique. The surface morphology of RVC-lipid nanoparticles was evaluated with field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). Particle size was measured using dynamic light scattering technique (DLS), X-ray diffraction (XRD) was performed to identify the crystallographic nature and Fourier transform infrared spectroscopy (FTIR) was used to measure changes in the chemical structures of the resveratrol and RVC-lipid nanoparticles. Results showed RVC-lipid nanoparticle had a characteristic amorphous structure, a mean particle sizes of 570 nm in DI water and 950 nm in ethanol, and an encapsulation efficiency of 63.82% in aqueous medium and 85.59% in ethanol medium. In-vitro release studies demonstrated a slow and sustained release of resveratrol governed by diffusion. Based on assays of antioxidant activity the scavenging activity of RVC-lipid nanoparticles Was inferior to that of resveratrol due to its prolonged release. We concluded that phospholipids are the potential carriers for resveratrol. (C) 2016 Elsevier B.V. All rights reserved.
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