4.5 Article

Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma

Related references

Note: Only part of the references are listed.
Article Infectious Diseases

Inhibiting DHN- and DOPA-melanin biosynthesis pathway increased the therapeutic value of itraconazole in Madurella mycetomatis infected Galleria mellonella

Wilson Lim et al.

Summary: This study discovered that Madurella mycetomatis produces DOPA-, pyomelanin and DHN-melanin in vivo. Inhibiting the DHN-melanin biosynthesis of M. mycetomatis increased the therapeutic value of the antifungal itraconazole in vivo.

MEDICAL MYCOLOGY (2022)

Article Infectious Diseases

The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma

Mickey Konings et al.

Summary: Mycetoma, caused by Madurella mycetomatis, is a challenging tropical infection with low treatment success rates. CIN-102, a synthetic oil resembling cinnamon oil, showed promising in vitro activity against M. mycetomatis and efficacy in reducing larval mortality in an infected model.

PLOS NEGLECTED TROPICAL DISEASES (2021)

Article Infectious Diseases

Madurella mycetomatis, the main causative agent of eumycetoma, is highly susceptible to olorofim

Wilson Lim et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

Article Infectious Diseases

Proteomic analysis of the processes leading to Madurella mycetomatis grain formation in Galleria mellonella larvae

Gerard Sheehan et al.

PLOS NEGLECTED TROPICAL DISEASES (2020)

Article Microbiology

In Vitro Activities of Ravuconazole and Isavuconazole against Dematiaceous Fungi

Hailin Zheng et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

Review Infectious Diseases

Madurella mycetomatis causing eumycetoma medical treatment: The challenges and prospects

Lamis Y. M. Elkheir et al.

PLOS NEGLECTED TROPICAL DISEASES (2020)

Article Parasitology

Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery

Martina Maccesi et al.

PARASITES & VECTORS (2019)

Article Microbiology

Screening the Pathogen Box for Identification of New Chemical Agents with Anti-Fasciola hepatica Activity

Claudia Machicado et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)

Review Oncology

Double Edge Sword Behavior of Carbendazim: A Potent Fungicide With Anticancer Therapeutic Properties

Karan Goyal et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2018)

Article Microbiology

Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus

Saskia du Pre et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

Article Multidisciplinary Sciences

Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus

Bernadette Geissel et al.

NATURE COMMUNICATIONS (2018)

Review Infectious Diseases

Mycetoma: a unique neglected tropical disease

Eduard E. Zijlstra et al.

LANCET INFECTIOUS DISEASES (2016)

Article Multidisciplinary Sciences

F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

Jason D. Oliver et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Infectious Diseases

A Madurella mycetomatis Grain Model in Galleria mellonella Larvae

Wendy Kloezen et al.

PLOS NEGLECTED TROPICAL DISEASES (2015)

Article Infectious Diseases

Madurella mycetomatis Is Highly Susceptible to Ravuconazole

Sarah Abdalla Ahmed et al.

PLOS NEGLECTED TROPICAL DISEASES (2014)

Review Infectious Diseases

Mycetoma Medical Therapy

Oliverio Welsh et al.

PLOS NEGLECTED TROPICAL DISEASES (2014)

Review Infectious Diseases

Global Burden of Human Mycetoma: A Systematic Review and Meta-analysis

Wendy W. J. van de Sande

PLOS NEGLECTED TROPICAL DISEASES (2013)

Article Microbiology

In Vitro Antifungal Activity of Isavuconazole against Madurella mycetomatis

Wendy Kloezen et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

Article Dermatology

Actinomycetoma and advances in its treatment

Oliverio Welsh et al.

CLINICS IN DERMATOLOGY (2012)

Article Public, Environmental & Occupational Health

Predictors of cure, amputation and follow-up dropout among patients with mycetoma seen at the Mycetoma Research Centre, University of Khartoum, Sudan

Hagir A. M. Zein et al.

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (2012)

Article Public, Environmental & Occupational Health

The safety and efficacy of itraconazole for the treatment of patients with eumycetoma due to Madurella mycetomatis

A. H. Fahal et al.

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE (2011)

Review Infectious Diseases

Use of Antifungal Combination Therapy: Agents, Order, and Timing

Melissa D. Johnson et al.

CURRENT FUNGAL INFECTION REPORTS (2010)

Article Multidisciplinary Sciences

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

Leah E. Cowen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Microbiology

In vitro activity of ravuconazole against 923 clinical isolates of nondermatophyte filamentous fungi

M Cuenca-Estrella et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)

Article Microbiology

In vitro activities of new antifungal agents against Chaetomium spp. and inoculum standardization

C Serena et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)

Article Microbiology

In vitro activities of ravuconazole (BMS-207147) against 541 clinical isolates of Cryptococcus neoformans

T Yamazumi et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)