Related references
Note: Only part of the references are listed.NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells
Ralitsa R. Madsen et al.
DISEASE MODELS & MECHANISMS (2021)
PI3K inhibitors are finally coming of age
Bart Vanhaesebroeck et al.
NATURE REVIEWS DRUG DISCOVERY (2021)
Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial
Peter Schmid et al.
JOURNAL OF CLINICAL ONCOLOGY (2020)
Pan-cancer analysis of whole genomes
Peter J. Campbell et al.
NATURE (2020)
The nf-core framework for community-curated bioinformatics pipelines
Philip A. Ewels et al.
NATURE BIOTECHNOLOGY (2020)
Landscape and function of multiple mutations within individual oncogenes
Yuki Saito et al.
NATURE (2020)
Why do pathway methods work better than they should?
Bence Szalai et al.
FEBS LETTERS (2020)
A metastasis map of human cancer cell lines
Xin Jin et al.
NATURE (2020)
Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups
Oscar M. Rueda et al.
NATURE (2019)
Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer
Fabrice Andre et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Cancer stemness, intratumoral heterogeneity, and immune response across cancers
Alex Miranda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner
Ralitsa R. Madsen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
FAIRLANE, a double-blind placebo-controlled randomized phase II trial of neoadjuvant ipatasertib plus paclitaxel for early triple-negative breast cancer
M. Oliveira et al.
ANNALS OF ONCOLOGY (2019)
Mutationally-activated PI3′-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase
J. Edward Van Veen et al.
ELIFE (2019)
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
Neil Vasan et al.
SCIENCE (2019)
PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9
Catherine M. Bell et al.
CANCERS (2019)
Metabolic signatures of cancer cells and stem cells
Andrew M. Intlekofer et al.
NATURE METABOLISM (2019)
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Francisco Sanchez-Vega et al.
CELL (2018)
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Tathiane M. Malta et al.
CELL (2018)
Linear regression and the normality assumption
Amand F. Schmidt et al.
JOURNAL OF CLINICAL EPIDEMIOLOGY (2018)
Perturbation-response genes reveal signaling footprints in cancer gene expression
Michael Schubert et al.
NATURE COMMUNICATIONS (2018)
Cancer-Associated PIK3CA Mutations in Overgrowth Disorders
Ralitsa R. Madsen et al.
TRENDS IN MOLECULAR MEDICINE (2018)
Molecular diagnosis of PIK3CA-related overgrowth spectrum (PROS) in 162 patients and recommendations for genetic testing
Paul Kuentz et al.
GENETICS IN MEDICINE (2017)
Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids
Pamela Riemer et al.
JOURNAL OF CELL BIOLOGY (2017)
Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
Sung-Bae Kim et al.
LANCET ONCOLOGY (2017)
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Aravind Subramanian et al.
CELL (2017)
A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Yiqun Zhang et al.
CANCER CELL (2017)
Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC
Ekta Khattar et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2017)
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity
Matthew T. Chang et al.
NATURE BIOTECHNOLOGY (2016)
TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data
Antonio Colaprico et al.
NUCLEIC ACIDS RESEARCH (2016)
Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling
L. Du et al.
ONCOGENE (2016)
PIK3CA-associated developmental disorders exhibit distinct classes of mutations with variable expression and tissue distribution
Ghayda Mirzaa et al.
JCI INSIGHT (2016)
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy
Elias E. Stratikopoulos et al.
CANCER CELL (2015)
Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations
Turgut Dogruluk et al.
CANCER RESEARCH (2015)
Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity
Alexandra Van Keymeulen et al.
NATURE (2015)
PIK3CAH1047R induces multipotency and multi-lineage mammary tumours
Shany Koren et al.
NATURE (2015)
limma powers differential expression analyses for RNA-sequencing and microarray studies
Matthew E. Ritchie et al.
NUCLEIC ACIDS RESEARCH (2015)
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
Nicholas McGranahan et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
The Molecular Signatures Database Hallmark Gene Set Collection
Arthur Liberzon et al.
CELL SYSTEMS (2015)
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Yang Liao et al.
BIOINFORMATICS (2014)
STAR: ultrafast universal RNA-seq aligner
Alexander Dobin et al.
BIOINFORMATICS (2013)
GSVA: gene set variation analysis for microarray and RNA-Seq data
Sonja Haenzelmann et al.
BMC BIOINFORMATICS (2013)
Ensuring the statistical soundness of competitive gene set approaches: gene filtering and genome-scale coverage are essential
Shailesh Tripathi et al.
NUCLEIC ACIDS RESEARCH (2013)
Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies
Ariella B. Hanker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Comprehensive molecular portraits of human breast tumours
Daniel C. Koboldt et al.
NATURE (2012)
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Christina Curtis et al.
NATURE (2012)
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
Ethan Cerami et al.
CANCER DISCOVERY (2012)
A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers
Nathan P. Palmer et al.
GENOME BIOLOGY (2012)
Luminal Expression of PIK3CA Mutant H1047R in the Mammary Gland Induces Heterogeneous Tumors
Dominique S. Meyer et al.
CANCER RESEARCH (2011)
A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs
Jonghwan Kim et al.
CELL (2010)
PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality
Elena Lopez-Knowles et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Allele-specific copy number analysis of tumors
Peter Van Loo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
Sherene Loi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
A scaling normalization method for differential expression analysis of RNA-seq data
Mark D. Robinson et al.
GENOME BIOLOGY (2010)
Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER plus breast cancer
Chad J. Creighton et al.
BREAST CANCER RESEARCH (2010)
Integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
Katherine Stemke-Hale et al.
CANCER RESEARCH (2008)
Regulatory networks define phenotypic classes of human stem cell lines
Franz-Josef Mueller et al.
NATURE (2008)
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
Ittai Ben-Porath et al.
NATURE GENETICS (2008)
PI3K pathway alterations in cancer: variations on a theme
T. L. Yuan et al.
ONCOGENE (2008)
A gene transcription signature of the Akt/mTOR pathway in clinical breast tumors
C. J. Creighton
ONCOGENE (2007)
PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer
Gizeh Perez-Tenorio et al.
CLINICAL CANCER RESEARCH (2007)
The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
Justin Lamb et al.
SCIENCE (2006)
Share Paper
