Journal
PLOS BIOLOGY
Volume 20, Issue 1, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.3001508
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Funding
- U.S. Department of Energy Joint Genome Institute, Department of Energy Office of Science User Facility [DE-AC02-05CH11231]
- DFG Leibniz grant
- Max Planck Society
- Natural Sciences and Engineering Research Council of Canada
- Genome British Columbia
- Canada Foundation for Innovation
- Compute/Calcul Canada
- U.S. Department of Energy Joint Genome Institute by the Office of Science of U.S. Department of Energy [DE-AC02-05CH11231]
- National Science Foundation [OCE-1536702/1536405]
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The anaerobic oxidation of methane coupled to sulfate reduction is a microbial process that involves a partnership between anaerobic methanotrophic archaea and sulfate-reducing bacteria. This study reconstructed and analyzed 28 ANME genomes, enabling a comparative analysis of all marine ANME clades. The findings suggest that methane production may have evolved from a methanotrophic ancestor.
The anaerobic oxidation of methane coupled to sulfate reduction is a microbially mediated process requiring a syntrophic partnership between anaerobic methanotrophic (ANME) archaea and sulfate-reducing bacteria (SRB). Based on genome taxonomy, ANME lineages are polyphyletic within the phylum Halobacterota, none of which have been isolated in pure culture. Here, we reconstruct 28 ANME genomes from environmental metagenomes and flow sorted syntrophic consortia. Together with a reanalysis of previously published datasets, these genomes enable a comparative analysis of all marine ANME clades. We review the genomic features that separate ANME from their methanogenic relatives and identify what differentiates ANME clades. Large multiheme cytochromes and bioenergetic complexes predicted to be involved in novel electron bifurcation reactions are well distributed and conserved in the ANME archaea, while significant variations in the anabolic C1 pathways exists between clades. Our analysis raises the possibility that methylotrophic methanogenesis may have evolved from a methanotrophic ancestor.
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