Journal
NANO-MICRO LETTERS
Volume 14, Issue 1, Pages -Publisher
SHANGHAI JIAO TONG UNIV PRESS
DOI: 10.1007/s40820-021-00747-8
Keywords
Microcapsule; Bone repair; Stem cell therapy; Microfluidics; Electrospray
Funding
- National Key Research and Development Program of China [2020YFA0908200]
- National Natural Science Foundation of China [52073060, 61927805]
- Shenzhen Fundamental Research Program [JCYJ20190813152616459]
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Stem cell transplantation has emerged as an alternative approach for bone repair due to its excellent biological activities and therapy effect. This study developed a novel core-shell microcapsule with a stem cell-laden core and a biomass shell, which showed good biocompatibility and therapeutic effect for bone defects.
Bone defects caused by trauma, tumor, or osteoarthritis remain challenging due to the lack of effective treatments in clinic. Stem cell transplantation has emerged as an alternative approach for bone repair and attracted widespread attention owing to its excellent biological activities and therapy effect. The attempts to develop this therapeutic approach focus on the generation of effective cell delivery vehicles, since the shortcomings of direct injection of stem cells into target tissues. Here, we developed a novel core-shell microcapsule with a stem cell-laden core and a biomass shell by using all-aqueous phase microfluidic electrospray technology. The designed core-shell microcapsules showed a high cell viability during the culture procedure. In addition, the animal experiments exhibited that stem cell-laden core-shell microcapsules have good biocompatibility and therapeutic effect for bone defects. This study indicated that the core-shell biomass microcapsules generated by microfluidic electrospray have promising potential in tissue engineering and regenerative medicine.
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