Journal
NANO-MICRO LETTERS
Volume 14, Issue 1, Pages -Publisher
SHANGHAI JIAO TONG UNIV PRESS
DOI: 10.1007/s40820-021-00753-w
Keywords
Multiplexed profiling; Extracellular vesicles; Exosomes; Liquid biopsy; Point-of-care; Biomarker
Funding
- EPSRC [EP/M006204/1]
- Michael J Fox Foundation
- Selfridges Group Foundation
- NIHR Oxford Biomedical Research Centre
- John Fell Fund [HMD00470]
- EPSRC [EP/M006204/1] Funding Source: UKRI
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Extracellular vesicles (EVs) play a crucial role in molecular trafficking, intercellular transport, and protein egress. They can be detected in bodily fluids and offer opportunities for biomarker discovery. Multiplexing platforms can achieve breakthroughs in analytical power, throughput, and consistency.
Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency.
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