Journal
MOLECULAR BRAIN
Volume 14, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13041-021-00877-5
Keywords
Reconsolidation; PTSD; Fear; Hippocampus; Retrieval
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil) [001]
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The research found that hippocampal CaMKII is essential for the restabilization of avoidance memory, and inhibiting CaMKII can erase learned avoidance responses.
Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses.
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