Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 92, Issue -, Pages 476-483Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2016.07.056
Keywords
Ionotropic gelation; Chitosan hydrogel; Tripolyphosphate/pyrophosphate
Funding
- Friuli-Venezia Giulia Regional Government [LR 47/78]
- Friuli-Venezia Giulia Regional Government
- European Social Fund
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Ionotropic gelation of chitosan by means of opposite charged ions represents an efficient alternative to covalent reticulation because of milder condition of use and, in general, higher biocompatibility of the resulting systems. In this work 90 degrees light scattering (turbidimetry), circular dichroism (CD) and H-1 NMR measurements have been performed to study the interactions between the biopolymer and ionic cross-linkers tripolyphosphate (TPP) and pyrophosphate (PPi) in dilute solutions. Thereafter, a dialysis based technique was exploited to fabricate tridimensional chitosan hydrogels based on both polyanions. Resulting matrices showed a different mechanical behavior because of their peculiar mesh-texture at micro/nano-scale: in the present contribution we demonstrate that TPP and PPi favor the formation of homogeneous and inhomogeneous systems, respectively. The different texture of networks could be exploited in future for the preparation of systems for the controlled release of molecules. (C) 2016 Elsevier B.V. All rights reserved.
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