Identification of Hub Genes and Immune Cell Infiltration Characteristics in Alzheimer's Disease

The purpose of this study was to identify hub genes closely correlated with Alzheimer's disease (AD) and their association with immune cell infiltration. In this work, 119 overlapping differentially expressed genes (DEGs) were obtained from GSE5281 and GSE122063 datasets through differential expression analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed on the 119 DEGs, revealing some important biological functions and key pathways. AD immune cell infiltration analysis revealed a significant difference in the proportion of immune cells between the AD group and the control group. Finally, correlation analysis between target hub genes and immune cells indicated that GFAP had a positive or negative correlation with some specific immune cells. Our results provided useful clues, which will help to explain the molecular mechanism of AD and search for precise prognostic markers and potential therapeutic targets.

Automated summary

This study identified hub genes closely correlated with Alzheimer's disease through differential expression analysis, and revealed their association with immune cell infiltration. Enrichment analysis and immune cell proportion analysis highlighted important biological functions, key pathways, and significant differences in immune cell proportions between the AD group and control group. Furthermore, correlation analysis showed that GFAP had both positive and negative associations with specific immune cells.