4.4 Article

Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds

Journal

INTERNATIONAL JOURNAL OF POLYMER SCIENCE
Volume 2021, Issue -, Pages -

Publisher

HINDAWI LTD
DOI: 10.1155/2021/4935642

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Funding

  1. Ministry of Education and Science of Ukraine
  2. National Research Foundation of Ukraine [2020.02/0022]

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This study synthesized hydrogels loaded with cefuroxime and investigated the antibiotic release rate and antibacterial activity of different materials, confirming the potential application of antimicrobial hydrogels in treating infected wounds.
Dextran/Sulfodextran-graft-polyacrylamide- and polyacrylamide-based hydrogels were synthesized by radical polymerization and loaded with cefuroxime to obtain antimicrobial wound dressings. Antibiotic release from the antibiotic-loaded hydrogels into an aqueous solution was studied by the HPLC-UV method. It is shown that cefuroxime-loaded Dextran/Sulfodextran-graft-polyacrylamide hydrogels release the antibiotic more slowly compared to polyacrylamide hydrogel with the same density of cross-links. Antibacterial activity of the synthesized materials was tested in vitro against wild strains of S. aureus, E. coli, and Klebsiella spp. The possibility of using the obtained antimicrobial hydrogels for the treatment of infected wounds was confirmed in vivo in a rat model.

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