Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 93, Issue -, Pages 1647-1652Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2016.04.029
Keywords
Carboxymethyl cellulose; Hybrid; Biomimetic mineralization; Drug delivery
Funding
- National Research Center in Cairo, Egypt [10130101]
Ask authors/readers for more resources
Hybrid materials contain polysaccharide based network and biomimetic calcium phosphate are potentially appropriate for bone repair and drug release. Novel hydrogel composed of carboxymethyl cellulose backbone grafted with crosslinked poly(dimethylaminoethyl methacrylate) CMC-g-PDMAEMA was subjected to biomimetic calcium phosphate mineralization through simulated body fluid. Infrared spectroscopy (IR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA) confirmed calcium phosphate mineralization while X-ray diffraction and transmission electron microscopy (TEM) results suggested that the deposited phase contains mineralized component of bone, hydroxyapatite. CMC-g-PDMAEMA hydrogels before and after calcium phosphate mineralization were investigated as a drug carrier and the results showed significant efficiency of the mineralized hydrogel to deliver bovine serum albumin (BSA). These results indicated that CMC-g-PDMAEMA/calcium phosphate could serve as a new class of multifunctional hybrid materials for various biomedical applications. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available