4.6 Article

Fibromodulin: A regulatory molecule maintaining cellular architecture for normal cellular function

Journal

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2016.09.023

Keywords

Cellular structure; Extracellular matrix; Fibromodulin; Proteoglycans

Funding

  1. Korean National Research Foundation (NRF) - Ministry of Education [NRF-2013R1A1A2059308]
  2. NRF grant - Republic of Korea (MSIP) [2014R1A2A2A01006324]

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Fibromodulin (FMOD) is a small leucine-rich proteoglycan that plays roles in a series of biological and pathophysiological processes. The interaction between FMOD and lysyl oxidase (LOX; collagen cross linking enzyme) helps regulate extracellular matrix composition, and thereby, provides a permissive environment for regulating cellular turnover. FMOD has been mostly studied in the context of matrix component assembly, but during recent years its association with muscle development, cell reprogramming, and the angiogenic program have demonstrated its activities well beyond extracellular matrix maintenance. In fact, the involvement of FMOD in these cellular processes places it the centrum of cellular behaviour and ultimately of tissue properties. Thus, a clear view of the impact FMOD has on tissue integrity would aid its exploitation for tissue modelling and in the treatment of different disorders. (C) 2016 Elsevier Ltd. All rights reserved.

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