Journal
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Volume 19, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ijerph19031864
Keywords
chronic kidney disease; renoprotective; kidney fibrosis; oxidative stress; inflammation; mangiferin
Funding
- National Research Foundation [2020R1I1A1A01072879, 2015H1D3A1062189]
- Brain Pool program - Ministry of Science and ICT through the National Research Foundation [2020H1D3A2A02110924]
- Japan Society for the Promotion of Science [20K17585]
- National Research Foundation of Korea [2015H1D3A1062189] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Grants-in-Aid for Scientific Research [20K17585] Funding Source: KAKEN
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Both acute and chronic kidney diseases are significant health issues worldwide. Synthetic therapeutics developed so far have unexpected effects, leading researchers to explore natural alternatives. Mangiferin, a natural compound from mango, has shown renoprotective potential against kidney diseases. Studies have demonstrated that mangiferin can attenuate renal inflammation and oxidative stress, improve renal function, and ameliorate structural changes in the kidney. However, further research is needed to understand the targeted delivery of mangiferin to the kidney for clinical use.
Both acute and chronic kidney diseases substantially contribute to the morbidities and mortality of patients worldwide. The existing therapeutics, which are mostly developed from synthetic sources, present some unexpected effects in patients, provoking researchers to explore potential novel alternatives. Natural products that have protective effects against various renal pathologies could be potential drug candidates for kidney diseases. Mangiferin is a natural polyphenol predominantly isolated from Mangifera indica and possesses multiple health benefits against various human ailments, including kidney disease. The main objective of this review is to update the renoprotective potentials of mangiferin with underlying molecular pharmacology and to highlight the recent development of mangiferin-based therapeutics toward kidney problems. Literature published over the past decade suggests that treatment with mangiferin attenuates renal inflammation and oxidative stress, improves interstitial fibrosis and renal dysfunction, and ameliorates structural alteration in the kidney. Therefore, mangiferin could be used as a multi-target therapeutic candidate to treat renal diseases. Although mangiferin-loaded nanoparticles have shown therapeutic promise against various human diseases, there is limited information on the targeted delivery of mangiferin in the kidney. Further research is required to gain insight into the molecular pharmacology of mangiferin targeting kidney diseases and translate the preclinical results into clinical use.
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