Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 75, Issue -, Pages 232-243Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2016.03.004
Keywords
Microbubbles; Protein corona; Flow cytometry; Opsonin proteins; Dysopsonin proteins; Bionano interactions
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Funding
- European Union's Seventh Framework Programme (EU FP7) under grant agreement Nanosolutions [309329]
- SFI PI Award [12/IA/1422]
- SFI Industry fellowship [15/IFA/3057]
- European Union's Seventh Framework Programme (EU FP7) under grant agreement QualityNano [262163]
- European Union's Seventh Framework Programme (EU FP7) under grant agreement 3MICRON [245572]
- Science Foundation Ireland (SFI) [15/IFA/3057] Funding Source: Science Foundation Ireland (SFI)
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Polymeric microbubbles (MBs) are gas filled particles composed of a thin stabilized polymer shell that have been recently developed as valid contrast agents for the combined use of ultrasonography (US), magnetic resonance imaging (MRI) and single photon emission computer tomography (SPECT) imaging. Due to their buoyancy, the commonly available approaches to study their behaviour in complex media are not easily applicable and their use in modern medicine requires such behaviour to be fully elucidated. Here we have used for the first time flow cytometry as a new high throughput approach that allows characterisation of the MB dispersion, prior to and after exposure in different biological media and we have additionally developed a method that allows characterisation of the strongly bound proteins adsorbed on the MBs, to fully predict their biological behaviour in biological milieu. (C) 2016 Published by Elsevier Ltd.
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