Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 75, Issue -, Pages 175-179Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2015.09.007
Keywords
Protein corona; Metal nanoclusters; Endocytosis; Cell imaging; Nanoprobes
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Funding
- KIT within the Helmholtz Program STN
- Deutsche Forschungsgemeinschaft (DFG) [GRK 2039]
- Carl-Zeiss-Stiftung
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Metal nanoclusters (NCs) are a new type of nanoprobe with great potential in various biological applications. For biocompatible and efficient utilization of NCs, a thorough understanding of their interactions with biological systems is highly important. Herein, we focus on recent studies addressing interactions between metal NCs and proteins as well as implications for their further biological application. These findings show that protein adsorption not only affects the photophysical properties of NCs, but also influences their subsequent biological behavior, i.e., cellular uptake and cytotoxicity. Moreover, specific protein-NC interactions have also been harnessed to develop novel protein discrimination strategies. (C) 2015 Elsevier Ltd. All rights reserved.
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