Journal
G3-GENES GENOMES GENETICS
Volume 12, Issue 2, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/g3journal/jkab434
Keywords
centrosome; mitosis; RNA localization; centrocortin
Categories
Funding
- NIH [5K12GM000680, 1F32GM128407, R01GM138544, 3R01G M138544-01S1]
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This study found that centrocortin (cen) is not essential for centriole duplication but contributes to centrosome separation in Drosophila embryos, based on time-lapse recordings of rapid syncytial divisions.
Centrosomes are microtubule-organizing centers that duplicate exactly once to organize the bipolar mitotic spindle required for error-free mitosis. Prior work indicated that Drosophila centrocortin (cen) is required for normal centrosome separation, although a role in centriole duplication was not closely examined. Through time-lapse recordings of rapid syncytial divisions, we monitored centriole duplication and the kinetics of centrosome separation in control vs cen null embryos. Our data suggest that although cen is dispensable for centriole duplication, it contributes to centrosome separation.
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