Journal
CELL REPORTS
Volume 37, Issue 11, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2021.110117
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Funding
- National Natural Science Foundation of China [31871107, 31930053, 81500752, 81525006, 81670864, 81730025, 820300 27, 8201001029]
- Strategy Priority Research Program of the Chinese Academy of Science [XDB32020200, KJZD-SW-L08, 2021 089]
- Beijing Science and Technology Q2 Project [Z181100001518002]
- Bureau of International Cooperation, Chinese Academy of Sciences [153311KYSB20160030]
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Abnormal visual experiences early in life, particularly amblyopia, have been found to impact the subcortical visual pathways of the adult human brain. This leads to selective alterations in the parvocellular layers of the lateral geniculate nucleus and corticotectal pathways, providing a neural basis for deficits in visual acuity, ocular motor control, and attention associated with amblyopia.
How abnormal visual experiences early in life influence human subcortical pathways is poorly understood. Using high-resolution fMRI and pathway-selective visual stimuli, we investigate the influence of amblyopia on response properties and the effective connectivity of subcortical visual pathways of the adult human brain. Compared to the normal and fellow eyes, stimuli presented to the amblyopic eye show selectively reduced response in the parvocellular layers of the lateral geniculate nucleus and weaker effective connectivity to V1. Compared to the normal eye, the response of the amblyopic eye to chromatic stimulus decreases in the superficial layers of the superior colliculus, while response of the fellow eye robustly increases in the deep SC with stronger connectivity from the visual cortex. Therefore, amblyopia leads to selective parvocellular alterations of the geniculostriate and corticotectal pathways. These findings provide the neural basis for amblyopic deficits in visual acuity, ocular motor control, and attention.
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