Journal
CELL REPORTS
Volume 38, Issue 2, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2021.110218
Keywords
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Categories
Funding
- AMED Research Program on Emerging and Reemerging Infectious Diseases [20fk0108539, 20fk0108542, 20fk0108403, 20fk0108163, 20fk0108518, 20fk0108146, 20fk0108270, 20fk0108413, 20fk0108451]
- AMED Research Program on HIV/AIDS [21fk0410046, 21fk0410033, 21fk0410039]
- AMED Japan Program for Infectious Diseases Research and Infrastructure [20wm0325009, 21wm0325009]
- JST SICORP [JPMJSC20U1, JPMJSC21U5]
- JST CREST [JPMJCR20H6, JPMJCR20H4]
- JSPS KAKENHI [18K07156, 21K07060, 18H05279, 19K06382, 18H02662, 21H02737]
- JSPS Fund for the Promotion of Joint International Research (Fostering Joint International Research) [18KK0447]
- JSPS Core-to-Core Program [JPJSCCA20190008]
- JSPS [DC1 19J20488]
- Ono Medical Research Foundation
- Ichiro Kanehara Foundation
- Lotte Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Daiichi Sankyo Foundation of Life Science
- Sumitomo Foundation
- Uehara Foundation
- Takeda Science Foundation
- Tokyo Biochemical Research Foundation
- Grant for Joint Research Projects of the Research Institute for Microbial Diseases, Osaka University
- Kumamoto University COVID-19 Research Projects (AMABIE)
- Joint Usage/Research Center Program of Institute for Frontier Life and Medical Sciences, Kyoto University
- Grants-in-Aid for Scientific Research [21H02737, 21K07060, 18KK0447, 19K06382, 18H02662, 18K07156, 18H05279] Funding Source: KAKEN
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This study reveals the increased infectivity and antibody evasion mechanism of the SARS-CoV-2 Lambda variant using pseudoviruses. The spike protein of the Lambda variant is more infectious than other variants due to specific mutations, and the RSYLTPGD246-253N mutation is responsible for antibody evasion and enhanced infection.
SARS-CoV-2 Lambda, a variant of interest, has spread in some South American countries; however, its virological features and evolutionary traits remain unclear. In this study, we use pseudoviruses and reveal that the spike protein of the Lambda variant is more infectious than that of other variants due to the T76I and L452Q mutations. The RSYLTPGD246-253N mutation, a unique 7-amino acid deletion in the N-terminal domain of the Lambda spike protein, is responsible for evasion from neutralizing antibodies and further augments antibody-mediated enhancement of infection. Although this mutation generates a nascent N-linked glycosylation site, the additional N-linked glycan is dispensable for the virological property conferred by this mutation. Since the Lambda variant has dominantly spread according to the increasing frequency of the isolates harboring the RSYLTPGD246-253N mutation, our data suggest that the RSYLTPGD246-253N mutation is closely associated with the substantial spread of the Lambda variant in South America.
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