Journal
CELL REPORTS
Volume 37, Issue 6, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2021.109969
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Funding
- Cornell Nanoscale Science and Technology Facility under the NSF Grant [ECCS-1542081]
- NIH [U01AI131348]
- Boehringer Ingelheim Fonds
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MicroRNAs (miRNAs) play a critical role in regulating the CD8+ T cell response to infection, with miR-29 acting as a developmental switch controlling the balance between effector response and memory generation in neonates and adults.
MicroRNAs (miRNAs) have emerged as critical regulators of cell fate in the CD8+ T cell response to infection. Although there are several examples of miRNAs acting on effector CD8+ T cells after infection, it is unclear whether differential expression of one or more miRNAs in the naive state is consequential in altering their long-term trajectory. To answer this question, we examine the role of miR-29 in neonatal and adult CD8+ T cells, which express different amounts of miR-29 only prior to infection and adopt profoundly different fates after immune challenge. We find that manipulation of miR-29 expression in the naive state is sufficient for age-adjusting the phenotype and function of CD8+ T cells, including their regulatory landscapes and long-term differentiation trajectories after infection. Thus, miR-29 acts as a developmental switch by controlling the balance between a rapid effector response in neonates and the generation of long-lived memory in adults.
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