4.8 Article

Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential

Journal

CELL REPORTS
Volume 38, Issue 2, Pages -

Publisher

CELL PRESS
DOI: 10.1016/j.celrep.2021.110234

Keywords

-

Categories

Funding

  1. Medical Research Council (Doctoral Training Program in Precision Medicine)
  2. University of Edinburgh
  3. MRC HGU Program [MC_UU_00007/9]
  4. European Research Council [ZF-MELCHEMBIO-648489]
  5. Melanoma Research Alliance [687306]

Ask authors/readers for more resources

This study identifies Tfap2b and a set of target genes that define an McSC population in the dorsal root ganglia of zebrafish, and shows that these McSCs play important roles during embryogenesis and in adulthood.
Melanocytes, the pigment-producing cells, are replenished from multiple stem cell niches in adult tissue. Although pigmentation traits are known risk factors for melanoma, we know little about melanocyte stem cell (McSC) populations other than hair follicle McSCs and lack key lineage markers with which to identify McSCs and study their function. Here we find that Tfap2b and a select set of target genes specify an McSC population at the dorsal root ganglia in zebrafish. Functionally, Tfap2b is required for only a few late-stage embryonic melanocytes, and is essential for McSC-dependent melanocyte regeneration. Fate mapping data reveal that tfap2b(+) McSCs have multifate potential, and are the cells of origin for large patches of adult melanocytes, two other pigment cell types (iridophores and xanthophores), and nerve-associated cells. Hence, Tfap2b confers McSC identity in early development, distinguishing McSCs from other neural crest and pigment cell lineages, and retains multifate potential in the adult zebrafish.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available