SARS-CoV-2 and COVID-19: revisiting the most important research questions

Article Multidisciplinary Sciences

Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2

Kaiyuan Sun et al.

Summary: The study reveals significant transmission heterogeneity of SARS-CoV-2, with a small proportion of individuals contributing to most secondary infections. Transmission risk is positively correlated with exposure duration and social interactions, modulated by demographic and clinical factors. During lockdown, transmission risk increases within families but decreases with isolation and quarantine measures for all types of contacts.

SCIENCE (2021)

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Editorial Material Multidisciplinary Sciences

Dissecting the early COVID-19 cases in Wuhan

Michael Worobey

SCIENCE (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms

Sarah A. Clark et al.

Summary: The study reveals that mutations occurring during the evolution of SARS-CoV-2 virus may lead to resistance against antibodies, posing challenges to long-term efficacy.

CELL (2021)

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Article Medicine, General & Internal

Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study

Zhenyu He et al.

LANCET (2021)

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Article Biochemistry & Molecular Biology

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

David S. Khoury et al.

Summary: The level of neutralizing antibodies is closely related to immune protection against COVID-19, playing a crucial role in protecting against detected infection and severe infection. Studies have shown that neutralizing titers will decline over time after vaccination, leading to decreased protection against SARS-CoV-2 infection.

NATURE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

Florian Kabinger et al.

Summary: Molnupiravir is an oral antiviral drug candidate that increases viral RNA mutations frequency and inhibits replication of SARS-CoV-2 by altering the substrate preference of RdRp. This two-step mutagenesis mechanism can explain the broad-spectrum antiviral activity of molnupiravir, making it a promising COVID-19 treatment option.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

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Article Public, Environmental & Occupational Health