Journal
ADVANCED HEALTHCARE MATERIALS
Volume 11, Issue 6, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202101448
Keywords
antibacterial activity; carbon dots; intrinsic bioactivity; photothermal optical coherence tomography; tumor-specific synergistic therapy
Funding
- National Natural Science Foundation of China [32071399, 11874021, 62175071]
- Science and Technology Program of Guangzhou [2019050001, 201904010323]
- Guangdong Basic and Applied Basic Research Foundation [2021A1515011988]
- Open Foundation of Key Laboratory of Optoelectronic Science and Technology for Medicine (Fujian Normal University), Ministry of Education, China [JYG2009]
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In this study, multifunctional carbon dots (GT-CDs) were developed for bioimaging, potent tumor therapy, and postoperative management. The GT-CDs exhibited high near-infrared photothermal conversion efficiency and tumor-specific cytotoxicity, allowing for synergistic antitumor therapy and promotion of wound healing.
Carbon dots (CDs) are considered as promising candidates with superior biocompatibilities for multimodel cancer theranostics. However, incorporation of exogenous components, such as targeting molecules and chemo/photo therapeutic drugs, is often required to improve the therapeutic efficacy. Herein, an all-in-one CDs that exhibit intrinsic bioactivities for bioimaging, potent tumor therapy, and postoperative management is proposed. The multifunctional CDs derived from gallic acid and tyrosine (GT-CDs) consist of a graphitized carbon core and N, O-rich functional groups, which endow them with a high near-infrared (NIR) photothermal conversion efficiency of 33.9% and tumor-specific cytotoxicity, respectively. A new imaging modality, photothermal optical coherence tomography, is introduced using GT-CDs as the contrast agent, offering the micrometer-scale resolution 3D tissue morphology of tumor. For cancer therapy, GT-CDs initiate the intracellular generation of reactive oxygen species in tumor cells but not normal cells, further induce the mitochondrial collapse and subsequent tumor cellular apoptosis. Combined with NIR photothermal treatment, synergistic antitumor therapy is achieved in vitro and in vivo. GT-CDs also promote the healing process of bacteria-contaminated skin wound, demonstrating their potential to prevent postoperative infection. The integrated theranostic strategy based on versatile GT-CDs supplies an alternative easy-to-handle pattern for disease management.
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