Activation of Antibiotic-Grafted Polymer Brushes by Ultrasound

The ultrasound-mediated activation of drugs from macromolecular architectures using the principles of polymer mechanochemistry (sonopharmacology) is a promising strategy to gain spatiotemporal control over drug activity. Yet, conceptual challenges limit the applicability of this method. Especially low drugloading content and low mechanochemical efficiency require the use of high carrier mass concentrations and prolonged exposure to ultrasound. Moreover, the activated drug is generally shielded by the hydrodynamic coil of the attached polymer fragment leading to a decreased drug potency. Here we present a carrier design for the ultrasound-induced activation of vancomycin, which is deactivated with its H-bond-complementary peptide target sequence. We show that the progression from mechanophore-centered linear chains to mechanophore-decorated polymer brushes increases drug-loading content, mechanochemical efficiency, and drug potency. These results may serve as a design guideline for future endeavors in the field of sonopharmacology.

Automated summary

The ultrasound-mediated activation of drugs from macromolecular structures is a promising strategy for achieving spatiotemporal control over drug activity. However, conceptual challenges such as low drugloading content and efficiency limit its applicability. A new carrier design has been proposed to increase drug-loading content, mechanochemical efficiency, and drug potency, providing a design guideline for future research in sonopharmacology.