4.4 Article

Host immune-inflammatory markers to unravel the heterogeneous outcome and assessment of patients with PD-L1 ≥50% metastatic non-small cell lung cancer and poor performance status receiving first-line immunotherapy

Journal

THORACIC CANCER
Volume 13, Issue 3, Pages 483-488

Publisher

WILEY
DOI: 10.1111/1759-7714.14256

Keywords

immunotherapy; inflammation; neutrophil-to-lymphocyte ratio (NLR); non-small cell lung cancer; performance status

Funding

  1. FPRC 5xmille Ministero Salute 2017 PTCRC-Intra 2020 'CTULung'
  2. Wellcome Trust [PS3416]
  3. NIHR Imperial Biomedical Research Center (BRC)
  4. Imperial Experimental Cancer Medicine Center (ECMC)
  5. NIHR Imperial BRC

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In this study, the role of immune-inflammatory surrogates, including NLR and pretreatment steroids, in predicting outcomes for patients with mNSCLC and poor PS undergoing first-line immunotherapy was investigated. The results showed that NLR, LDH, and pretreatment steroids were significant prognostic factors for overall survival and progression-free survival. Patients were classified into favorable, intermediate, and poor-risk groups based on their LIPS score, which had significant differences in 1-year OS and median PFS.
Background Patients with programmed cell death-ligand 1 (PD-L1) >= 50% metastatic non-small cell lung cancer (mNSCLC) and ECOG performance status (PS) of 2 treated with first-line immunotherapy have heterogeneous clinical assessment and outcomes. Methods To explore the role of immune-inflammatory surrogates by the validated lung immuno-oncology prognostic score (LIPS) score, including the neutrophil-to-lymphocyte ratio (NLR) and the pretreatment use of steroids, alongside other prognostic variables. A retrospective analysis of 128 patients with PS2 and PD-L1 >= 50% mNSCLC treated between April 2018 and September 2019 with first-line pembrolizumab in a real-world setting was performed. Results With a median follow-up of 15.3 months, the 1-year overall survival (OS) and median progression-free survival (PFS) were 32.3% (95% CI: 30.9-33.9) and 3.3 months (95% CI: 1.8-4.7), respectively. The NLR, lactate dehydrogenase (LDH) and pretreatment steroids results were the only significant prognostic factors on the univariate analysis and independent prognostic factors by the multivariate analysis on both OS and PFS. The LIPS score, including the NLR and pretreatment steroids, identified 29 (23%) favourable-risk patients, with 0 factors, 1-year OS of 67.6% and median PFS of 8.2 months; 57 (45%) intermediate-risk patients, with 1 factor, 1-year OS 32.1% and median PFS 2.7 months; 42 (33%) poor-risk patients, with both factors, 1-year OS of 10.7% and median PFS of 1.2 months. Conclusions The assessment of pre-existing imbalance of the host immune response by combined blood and clinical immune-inflammatory markers may represent a way to unravel the heterogeneous outcome and assessment of patients with mNSCLC and poor PS in the immune-oncology setting.

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