Journal
STEM CELL RESEARCH & THERAPY
Volume 13, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13287-021-02690-2
Keywords
Mesenchymal stem cells (MSCs); Immunomodulation; Peripheral nerve injury; Review
Funding
- Medical Research and Development Projects [AWS17J005]
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The article summarizes the interactions between MSCs, immune cells, and inflammatory cytokines following PNI, with a focus on the immunosuppressive role of MSCs. Additionally, the immunomodulatory potential of MSC-derived extracellular vesicles as a cell-free treatment for PNI is discussed.
Various immune cells and cytokines are present in the aftermath of peripheral nerve injuries (PNI), and coordination of the local inflammatory response is of great significance for the recovery of PNI. Mesenchymal stem cells (MSCs) exhibit immunosuppressive and anti-inflammatory abilities which can accelerate tissue regeneration and attenuate inflammation, but the role of MSCs in the regulation of the local inflammatory microenvironment after PNI has not been widely studied. Here, we summarize the known interactions between MSCs, immune cells, and inflammatory cytokines following PNI with a focus on the immunosuppressive role of MSCs. We also discuss the immunomodulatory potential of MSC-derived extracellular vesicles as a new cell-free treatment for PNI.
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