Journal
STEM CELL RESEARCH & THERAPY
Volume 13, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13287-022-02700-x
Keywords
Avulsion; Traumatic injury; Periodontal ligament (PDL); Periodontal ligament stem cells (PDLSCs); Cell-based PDL regeneration; Cell sheet; Tooth replantation; Animal models; Mini-swine; Dog
Funding
- National Institutes of Health [R01 DE019156]
- American Association of Endodontists Foundation
- Henry M. Goldman School of Dental Medicine, Boston University
- University of Tennessee Health Science Center
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This review discusses the limitations of current management protocols for avulsed teeth, the application of cell-based therapy in periodontal ligament regeneration, the challenges of PDL regeneration on denuded roots, and the establishment of a new clinical protocol based on cell-based PDL regeneration studies.
Management of avulsed teeth after replantation often leads to an unfavorable outcome. Damage to the thin and vulnerable periodontal ligament is the key reason for failure. Cell- or stem cell-based regenerative medicine has emerged in the past two decades as a promising clinical treatment modality to improve treatment outcomes. This concept has also been tested for the management of avulsed teeth in animal models. This review focuses on the discussion of limitation of current management protocols for avulsed teeth, cell-based therapy for periodontal ligament (PDL) regeneration in small and large animals, the challenges of de novo regeneration of PDL on denuded root in the edentulous region using a mini-swine model, and establishing a prospective new clinical protocol to manage avulsed teeth based on the current progress of cell-based PDL regeneration studies.
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