The characteristics of choriocapillaris flow void in the unilateral polypoidal choroidal vasculopathy fellow eyes

To evaluate the morphological characteristics of flow void (FV) in the fellow eyes of the unilateral polypoidal choroidal vasculopathy (PCV). Fifty PCV fellow eyes (PCVF) and 31 age-matched normal ocular circulation controls were recruited in this retrospective study. The number of FV was analyzed according to the size in a centered 5 x 5 mm swept source optical coherence tomography angiography scans. We used indocyanine green angiography images to determine whether choroidal vascular hyperpermeability (CVH) has occurred. For the PCVF, the prevalence rate of CVH was 70% (35 of 50) The number of FVs was significantly lower in 400-25,000 mu m(2) (P = 0.005), 400-500 mu m(2) (P = 0.001), 525-625 mu m(2) (P = 0.001) and 650-750 mu m(2) (P = 0.018). compared to the controls. And showed no difference in size from 775 to 1125 mu m(2) between the two groups. The area under the receiver operating characteristic curve of PCVF with CVH and controls was 0.94 (95% CI 0.88-1.00) (P < 0.001). We found that the number of small FVs was significantly lower in the PCV fellow eyes than that in the eyes with control group.

Automated summary

The study found that the number of flow voids (FVs) in fellow eyes of unilateral polypoidal choroidal vasculopathy (PCV) was significantly lower compared to the control group, indicating a higher prevalence rate of choroidal vascular hyperpermeability (CVH) in PCVF.