Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 48, Issue 6, Pages 607-613Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2016.09.014
Keywords
Polymyxins; Synergy; Combinations; Acinetobacter baumannii; Klebsiella pneumoniae; Pseudomonas aeruginosa
Funding
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01AI111990]
Ask authors/readers for more resources
The proliferation of extensively drug-resistant Gram-negative pathogens has necessitated the therapeutic use of colistin and polymyxin B. However, treatment failures with polymyxin monotherapies and the emergence of polymyxin resistance have catalysed the search for polymyxin combinations that synergistically kill polymyxin-susceptible and-resistant organisms. This mini-review examines recent (20112016) in vitro and in vivo studies that have attempted to identify synergistic polymyxin combinations against Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii. Clinical evidence for the use of combination regimens is also discussed. (C) 2016 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available