Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 47, Issue 6, Pages 457-465Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2016.03.019
Keywords
Antimicrobial resistance; Escherichia coli ST410; Epidemiology
Funding
- BMBF through the German Aerospace Center (DLR)
- BMBF within the German Center for Infection Research (DZIF) [8000 701-3, TI06.001]
Ask authors/readers for more resources
Multidrug-resistant Escherichia coli encoding CTX-M-type extended-spectrum beta-lactamases (ESBLs) are isolated in increasing numbers from humans, companion animals and livestock, raising concern regarding the exchange and spread of isolates in these populations. In this study, whole-genome sequencing of CTX-M-15-producing E. coli isolates recently sampled from humans, companion animals, livestock and farm environments was performed. In total, 26 different sequence types (STs) were detected, of which ST410 was the most frequent and was the only ST present in all populations studied. Five clades (designated A-E) were detected within the ST410 isolates. In particular, isolates of clade B were present in all four populations and had core genomes that differed by less than 70 single nucleotide polymorphisms (SNPs). Isolates of clades B and C were also clonally marked, exhibiting identical chromosomal insertions of bla(CTX-M-15) at distinct loci. These data provide strong evidence for the clonal dissemination of specific clades of CTX-M-15-producing E. coli ST410 in human and animal populations. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available