Quadriceps physiological response during the 1-min sit-to-stand test in people with severe COPD and healthy controls

We compared quadriceps oxygenation and surface electromyography (sEMG) responses during the 1-min sit-to-stand (1STS) in 14 people with severe COPD and 12 controls, in whom cardiorespiratory response, near-infrared spectroscopy signals (oxy [Hb-Mb], deoxy [Hb-Mb], total [Hb-Mb], and SmO2) and sEMG signals of the quadriceps were recorded. Time duration of each sit-to-stand cycle and the total work performed during the 1STS were measured. The quadriceps oxygenation parameters were normalized by reporting their values according to the total work during 1STS. The rate of sit-to-stand maneuvers decelerated in people with COPD leading to smaller total work compared with controls. The pattern of quadriceps oxygenation response during 1STS was similar between groups. However, in COPD, the recovery after 1STS was characterized by larger overshoots in oxy [Hb-Mb], total [Hb-Mb], and SmO2. When corrected for the cumulative total work, the increase in muscle O-2 extraction (deoxy [Hb-Mb]) during the first 30 s of recovery was greater in people with COPD compared to controls. Quadriceps sEMG changes suggestive of a fatiguing contraction pattern was observed only in people with COPD. All together, these results highlighted physiological misadaptation of people with severe COPD to the 1STS.

Automated summary

In this study, the oxygenation and electromyography responses in the quadriceps during the 1-min sit-to-stand (1STS) were compared between individuals with severe COPD and controls. The results showed that individuals with COPD had a slower rate of sit-to-stand maneuvers, resulting in less total work compared to controls. During the recovery period, individuals with COPD exhibited larger overshoots in oxygenation parameters. Additionally, only individuals with COPD showed signs of a fatiguing contraction pattern in the quadriceps.