Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-01223-4
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Funding
- Ministry of Higher Education, Malaysia
- Ministry of Science, Technology and Innovation, Malaysia [FRGS-MRSA/1/2018/SKK08/UM/01/1 (MO012-2017), MO002-2019]
- University of Malaya [RU005-2020]
- [UM.0000877/KWJ.AK]
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The COVID-19 pandemic first emerged in Malaysia in January 2020, with a total of 1,979,698 confirmed cases reported as of September 12, 2021. The study identified multiple independent introductions of SARS-CoV-2 into Malaysia, with a new B.1.524(G) lineage detected during the second and third waves of the epidemic. This lineage carried unique genetic variations, including mutations in the Spike protein and 5'UTR. The sequential appearance of mutations suggested a spread from Sabah to Selangor within Malaysia.
The COVID-19 pandemic first emerged in Malaysia in Jan 2020. As of 12th Sept 2021, 1,979,698 COVID-19 cases that occurred over three major epidemic waves were confirmed. The virus contributing to the three epidemic waves has not been well-studied. We sequenced the genome of 22 SARS-CoV-2 strains detected in Malaysia during the second and the ongoing third wave of the COVID-19 epidemic. Detailed phylogenetic and genetic variation analyses of the SARS-CoV-2 isolate genomes were performed using these newly determined sequences and all other available sequences. Results from the analyses suggested multiple independent introductions of SARS-CoV-2 into Malaysia. A new B.1.524(G) lineage with S-D614G mutation was detected in Sabah, East Malaysia and Selangor, Peninsular Malaysia on 7th October 2020 and 14th October 2020, respectively. This new B.1.524(G) group was not the direct descendant of any of the previously detected lineages. The new B.1.524(G) carried a set of genetic variations, including A701V (position variant frequency = 0.0007) in Spike protein and a novel G114T mutation at the 5'UTR. The biological importance of the specific mutations remained unknown. The sequential appearance of the mutations, however, suggests that the spread of the new B.1.524(G) lineages likely begun in Sabah and then spread to Selangor. The findings presented here support the importance of SARS-CoV-2 full genome sequencing as a tool to establish an epidemiological link between cases or clusters of COVID-19 worldwide.
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