Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-99725-8
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Funding
- National Institutes of Health [NIH 1DP2HL127776-01, NIH 5R01HL149369]
- National Science Foundation Career Award [1454365]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1454365] Funding Source: National Science Foundation
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This study evaluated the use of NIRS-integrated RFA catheters for monitoring lesion progression, both ex vivo and in vivo. The results showed that the predictive model based on spectral features correlated well with measured lesion dimensions, and the in vivo pilot studies demonstrated consistent contact discrimination and accurate lesion depth parameters. NIRS-empowered catheters are well suited for monitoring myocardial response to RF ablation and optimizing treatment efficacy.
There are currently limited means by which lesion formation can be confirmed during radiofrequency ablation procedures. The purpose of this study was to evaluate the use of NIRS-integrated RFA catheters for monitoring irrigated lesion progression, ex vivo and in vivo. Open-irrigated NIRS-ablation catheters with optical fibers were fabricated to sample tissue diffuse reflectance. Spectra from 44 irrigated lesions and 44 non-lesion sites from ex vivo swine hearts (n = 15) were used to train and evaluate a predictive model for lesion dimensions based on key spectral features. Additional studies were performed in diluted blood to assess NIRS signatures of catheter-tissue contact status. Finally, the potential of NIRS-RFA catheters for guiding lesion delivery was evaluated in a set of in vivo pilot studies conducted in healthy pigs (n = 4). Model predictions for lesion depth (R = 0.968), width (R = 0.971), and depth percentage (R = 0.924) correlated well with measured lesion dimensions. In vivo deployment in preliminary trials showed robust translational consistency of contact discrimination (P < 0.0001) and lesion depth parameters (< 3% error). NIRS empowered catheters are well suited for monitoring myocardial response to RF ablation and may provide useful intraprocedural feedback for optimizing treatment efficacy alongside current practices.
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