Journal
NUTRIENTS
Volume 14, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/nu14010015
Keywords
vitamin D; hs-CRP; low-grade inflammation; COPSAC; 25(OH)D; pregnancy; children
Categories
Funding
- Lundbeck Foundation [R16-A1694]
- Ministry of Health [903516]
- Danish Council for Strategic Research [0603-00280B]
- Capital Region Research Foundation
- European Research Council (ERC) [946228]
- NHLBI [R01HL141826]
- European Research Council (ERC) [946228] Funding Source: European Research Council (ERC)
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This study found associations between early life trajectories and 25(OH)D levels with hs-CRP concentrations. In two Danish mother-child cohorts, the researchers observed associations between 25(OH)D concentrations during pregnancy, infancy, and childhood with hs-CRP levels.
Vitamin D deficiency and elevated high sensitivity C-reactive protein (hs-CRP) have been associated with several health outcomes, but knowledge on early life trajectories and association between 25 hydroxyvitamin D (25(OH)D) and hs-CRP is lacking. We investigated the association between longitudinal measurements of 25(OH)D and hs-CRP, respectively, from pregnancy to childhood and throughout childhood in two Danish mother-child cohorts-the COPSAC(2010) and COPSAC(2000). In COPSAC(2010), there was an association between 25(OH)D concentrations at week 24 in pregnancy and at age 6 months in childhood (n = 633): estimate (95% CI); 0.114 (0.041;0.187), p = 0.002, and between 25(OH)D at age 6 months and 6 years (n = 475): 0.155 (0.083;0.228), p < 0.001. This was also demonstrated in the COPSAC(2000) cohort between 25(OH)D concentrations in cord blood and at age 4 years (n = 188): 0.294 (0.127;0.461), p < 0.001 and at age 6 months and 4 years (n = 264): 0.260 (0.133;0.388), p < 0.001. In COPSAC(2000), we also found an association between hs-CRP at age 6 months and 12 years in childhood (n = 232): 0.183 (0.076;0.289), p < 0.001. Finally, we found a negative association between the cross-sectional measurements of 25(OH)D and hs-CRP at age 6 months (n = 613) in COPSAC(2010): -0.004 (-0.008;-0.0004), p = 0.030, but this was not replicated in COPSAC(2000). In this study, we found evidence of associations across timepoints of 25(OH)D concentrations from mid-pregnancy to infancy and through childhood and associations between hs-CRP levels during childhood, although with weak correlations. We also found a negative cross-sectional association between 25(OH)D and hs-CRP concentrations in COPSAC(2010) proposing a role of vitamin D in systemic low-grade inflammation, though this association was not present in COPSAC(2000).
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