Journal
NUTRIENTS
Volume 13, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/nu13124425
Keywords
pancreatic cancer; gut microbiota; prebiotics; probiotics; next-generation probiotics; synbiotics; postbiotics; fecal microbiota transplantation
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Dysbiosis of gut microbiota may influence tumorigenic pathways, trigger pancreatic cancer development, and modulate tumor aggressiveness and microenvironment. Strategies such as prebiotics, probiotics, and next-generation probiotics can potentially enhance pancreatic cancer treatment outcomes and improve patients' quality of life.
Gut microbiota plays a significant role in the human body providing many beneficial effects on the host. However, its dysbiotic alterations may affect the tumorigenic pathway and then trigger the development of pancreatic cancer. This dysbiosis can also modulate the aggressiveness of the tumor, influencing the microenvironment. Because pancreatic cancer is still one of the most lethal cancers worldwide with surgery as the only method that influences prognosis and has curative potential, there is a need to search for other strategies which will enhance the efficiency of standard therapy and improve patients' quality of life. The administration of prebiotics, probiotics, next-generation probiotics (Faecalibacterium prausnitzii, Akkermansia muciniphila), synbiotics, postbiotics, and fecal microbiota transplantation through multiple mechanisms affects the composition of the gut microbiota and may restore its balance. Despite limited data, some studies indicate that the aforementioned methods may allow to achieve better effect of pancreatic cancer treatment and improve therapeutic strategies for pancreatic cancer patients.
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