Journal
NUTRIENTS
Volume 14, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/nu14030586
Keywords
fertility; energy metabolism; creatine; nutrition; creatine kinase
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Male fertility decline is a global public health problem, and finding efficient biomarkers and interventions to enhance fertility is of utmost importance. Creatine, due to its role in sperm energy metabolism, has been recognized as a potential candidate for promoting male fertility.
Male fertility has been declining globally over the past several decades, advancing from a personal issue to a public health problem. Beyond any doubt, a reduction in fertility (often characterized by low sperm count or motility) can severely threaten reproductive health and lifecourse framework in a long-term fashion. Aside from uncovering the currently unknown etiology of modern-day male infertility, the scientific and medical community faces a double burden: finding an efficient biomarker of impaired fertility and exploring any intervention that can act to enhance fertility. A plethora of nutritional compounds have been recognized as possible modulators of semen quality, and specific dietary patterns and nutrients appear to be accompanied by a lower risk of male infertility. Creatine, a conditionally essential nutrient, has caught attention as a male fertility-promoting candidate due to its role in sperm energy metabolism. This mini-review describes the creatine-related bioenergetics of spermatozoa, explores a connection between creatine levels and sperm quality in men, and critically examines available evidence for interventional studies with creatine to affect sperm viability.
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