Journal
NUTRIENTS
Volume 13, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/nu13113915
Keywords
Roseburia; Citrus Fruit Extract; gut microbiota; short-chain fatty acids (SCFA); in vitro model; TIM-2
Categories
Funding
- BioActor
- Dutch Province of Limburg [HEFI-1]
- Maastricht University-campus Venlo
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The study found that the polyphenols in Citrus Fruit Extract (CFE) can modulate the composition and activity of gut microbiota by increasing beneficial bacteria and shifting short-chain fatty acid production. This may help increase fat oxidation and stimulate the secretion of appetite-suppressive neuropeptides in overweight and obese individuals.
The effect of a Citrus Fruit Extract high in the polyphenols hesperidin and naringin (CFE) on modulation of the composition and activity of the gut microbiota was tested in a validated, dynamic in vitro model of the colon (TIM-2). CFE was provided at two doses (250 and 350 mg/day) for 3 days. CFE led to a dose-dependent increase in Roseburia, Eubacterium ramulus, and Bacteroides eggerthii. There was a shift in production of short-chain fatty acids, where acetate production increased on CFE, while butyrate decreased. In overweight and obesity, acetate has been shown to increase fat oxidation when produced in the distal gut, and stimulate secretion of appetite-suppressive neuropeptides. Thus, the data in the in vitro model point towards mechanisms underlying the effects of the polyphenols in CFE with respect to modulation of the gut microbiota, both in composition and activity. These results should be confirmed in a clinical trial.
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