Journal
NUTRIENTS
Volume 14, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/nu14030431
Keywords
diabetes mellitus; streptozotocin; creatine; histopathological and histomorphometric analyses; antioxidant response
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [001-CAPES]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [447222/2014-7, 447026/2014-3]
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Creatine supplementation as an adjuvant therapy for diabetes mellitus is controversial, as it does not seem to improve diabetes-related injuries and may even cause tissue damage in other areas.
Diabetes mellitus (DM) is a worldwide health concern, and projections state that cases will reach 578 million by 2030. Adjuvant therapies that can help the standard treatment and mitigate DM effects are necessary, especially those using nutritional supplements to improve glycemic control. Previous studies suggest creatine supplementation as a possible adjuvant therapy for DM, but they lack the evaluation of potential morphological parameters alterations and tissue injury caused by this compound. The present study aimed to elucidate clinical, histomorphometric, and histopathological consequences and the cellular oxidative alterations of creatine supplementation in streptozotocin (STZ)-induced type 1 DM rats. We could estimate whether the findings are due to DM or the supplementation from a factorial experimental design. Although creatine supplementation attenuated some biochemical parameters, the morphological analyses of pancreatic and renal tissues made clear that the supplementation did not improve the STZ-induced DM1 injuries. Moreover, creatine-supplemented non-diabetic animals were diagnosed with pancreatitis and showed renal tubular necrosis. Therefore, even in the absence of clinical symptoms and unaltered biochemical parameters, creatine supplementation as adjuvant therapy for DM should be carefully evaluated.
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