Journal
NUTRIENTS
Volume 14, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/nu14040839
Keywords
anemia; pregnancy; ferritin; transferrin saturation
Categories
Funding
- Ministry of Education, Science, Sports, and Culture of Japan [JP19K1865709]
- Hokkaido University Center of Innovation (JST COI) [JPMJCE1301]
Ask authors/readers for more resources
This study found that hemoglobin levels during the first trimester of pregnancy are efficient predictors of anemia occurring during the third trimester. In a longitudinal assessment of 231 healthy Japanese women, it was observed that women with lower red blood cell count, hemoglobin, hematocrit, and ferritin levels during the first trimester were more likely to develop anemia in the third trimester.
It is undetermined which blood variables related to iron storage during the first trimester of pregnancy could efficiently predict anemia occurring during the third trimester. Red blood cell count (RBC), hemoglobin concentration, hematocrit, ferritin, iron, and total iron binding capacity (TIBC) were assessed longitudinally during the first, second, and third trimesters of 231 healthy Japanese women. None of the patients had anemia in the first trimester and none used iron supplementation before the second trimester blood test. Anemia was defined as hemoglobin (Hb) < 11 g/dL for the first trimester and Hb < 10.0 g/dL for the third trimester. Forty-seven (20%) women developed anemia in the third trimester. The first trimester RBC, Hb, hematocrit, and ferritin levels were significantly lower in women with third-trimester anemia than those without anemia. The first trimester hemoglobin level exhibited a greater area under the curve of the receiver operating characteristic curve for prediction of the third trimester anemia than other blood variables; the optimal cut-off (12.6 g/dL) of hemoglobin yielded a sensitivity of 83% (39/47). First trimester hemoglobin levels were significantly better predictors of anemia during the third trimester than the indices of iron storage, including serum iron, ferritin, and TIBC levels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available