Journal
NUTRIENTS
Volume 13, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/nu13113697
Keywords
intermittent fasting; continuous glucose monitor; obesity; pediatrics; adolescents
Categories
Funding
- National Center for Advancing Translational Science (NCATS) of the U.S. National Institutes of Health [UL1TR001855]
- NIH/NCRR SC-CTSI [UL1 TR000130]
- National Institute on Minority Health and Health Disparities (NIMHD) Obesity Health Disparities Research Center [U54MD000502]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [R01HD092483]
- National Cancer Institute (NCI) [1R01CA258222]
- [(1) UL1TR001855]
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The study found that TLE combined with CGM may be a feasible and safe approach for treating adolescents with obesity. Most adolescents assigned to the TLE group reported that limiting their eating window and wearing a CGM was feasible without negative impact on daily functioning or adverse events. Additionally, there were no significant differences between the experimental groups in terms of weight loss, dietary intake, physical activity, eating behaviors, and quality of life. Further research in larger samples and with longer intervention durations is needed to confirm these findings.
Due to its simplicity, time-limited eating (TLE) may represent a more feasible approach for treating adolescents with obesity compared to other caloric restriction regimens. This pilot study examines the feasibility and safety of TLE combined with continuous glucose monitoring (CGM) in adolescents. Fifty adolescents with BMI & GE;95th percentile were recruited to complete a 12-week study. All received standard nutritional counseling, wore a CGM daily, and were randomized to: (1) Prolonged eating window: 12 h eating/12 h fasting + blinded CGM; (2) TLE (8 h eating/16 h fasting, 5 days per week) + blinded CGM; (3) TLE + real-time CGM feedback. Recruitment, retention, and adherence were recorded as indicators of feasibility. Weight loss, dietary intake, physical activity, eating behaviors, and quality of life over the course of the intervention were explored as secondary outcomes. Forty-five participants completed the study (16.4 & PLUSMN; 1.3 years, 64% female, 49% Hispanic, 75% public insurance). There was high adherence to prescribed eating windows (TLE 5.2 d/wk [SD 1.1]; control 6.1 d/wk [SD 1.4]) and daily CGM wear (5.85 d/wk [SD 4.8]). Most of the adolescents (90%) assigned to TLE reported that limiting their eating window and wearing a CGM was feasible without negative impact on daily functioning or adverse events. There were no between-group difference in terms of weight loss, energy intake, quality of life, physical activity, or eating behaviors. TLE combined with CGM appears feasible and safe among adolescents with obesity. Further investigation in larger samples, with a longer intervention duration and follow-up assessments are needed.
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