Journal
NUTRIENTS
Volume 13, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/nu13124387
Keywords
Wikstroemia ganpi; atopic dermatitis; tilianin 5-methyl ether; luteolin 7-methyl ether; interleukin 4
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Funding
- Bio & Medical Technology Development Program of the National Research Foundation (NRF) - Ministry of Science ICT [NRF-2019M3A9I3080263, NRF-2019M3A9I3080265, NRF-2019M3A9I3080266]
- National Research Foundation of Korea [2019M3A9I3080265, 2019M3A9I3080266] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Plants of the genus Wikstroemia have been traditionally used in China for treating various inflammatory diseases. This study isolated compounds from Wikstroemia ganpi and found that luteolin 7-methyl ether may be a potential therapeutic agent for atopic dermatitis by reducing mRNA expressions of inflammatory markers.
Plants of the genus Wikstroemia are traditionally used in China to treat various inflammatory diseases. The purpose of this study was to isolate the components of Wikstroemia ganpi (Siebold & Zucc.) Maxim., to evaluate their anti-atopic activities and to identify candidates with anti-atopic therapeutics. A total of 24 compounds were isolated by bioassay-guided separation, including one novel compound, which was tilianin 5-methyl ether. The anti-atopic activities of the isolated compounds were determined using TNF-alpha-treated RBL-2H3 cells and HaCaT cells. The mRNA expressions of IL-4, IL-6, GM-CSF, G-CSF and TRPV1 were reduced by luteolin 7-methyl ether. The study shows that the luteolin 7-methyl ether isolated from W. ganpi is a potential therapeutic agent for the treatment of atopic dermatitis.
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