Journal
NUTRIENTS
Volume 13, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/nu13113951
Keywords
antiviral therapies; arginine; cytokine storm; coronavirus; COVID-19; endothelium; immune response; immunity; inflammation; nitric oxide; nitrosylation; oxidative stress; ROS; SARS-CoV-2; T cells; viral infections
Categories
Funding
- National Institutes of Health (NIH) [R01HL146691, R01-DK123259, R01-HL159062, R01-DK033823, R56-AG066431, T32-HL144456, R00DK107895]
- Irma T. Hirschl Trust
- Monique-Weill-Caulier Trust
- Diabetes Action Research and Education Foundation
- American Heart Association [AHA-21POST836407, AHA-20POST35211151]
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L-Arginine may play a crucial role in COVID-19 by affecting endothelial cells and the immune system, and could potentially serve as a therapeutic tool based on recent clinical experimentations.
L-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.
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